Drug Design - Tag - Xiaopeng Xuhttps://xu-xp.com/tags/drug-design/Drug Design - Tag - Xiaopeng XuHugo -- gohugo.ioenxiaopeng.xu@kaust.edu.sa (Xiaopeng Xu)xiaopeng.xu@kaust.edu.sa (Xiaopeng Xu)Sun, 27 Jun 2021 00:00:00 +0000药物设计笔记https://xu-xp.com/posts/drug_design_notes/Sun, 27 Jun 2021 00:00:00 +0000xiaopeng.xu@kaust.edu.sa (Xiaopeng Xu)https://xu-xp.com/posts/drug_design_notes/导论

概述

创新药物发现—从基因到药物

药物 R&D

药物设计 3W

  • Why?

    • Unmet medical needs

    • Time-scale

    • Success rate

  • What?

    • Disease mechanism-Target identification & validation

    • Lead generation

    • Lead optimization

  • How?

    • Drug Design –The application of CADD in drug design

    • Bioinformatics, proteomics, Combi Chem/HTS

    • Target-drug interaction mode

    • Early ADME/T evaluation

药物设计内涵：药物研究模式的转变

Lee JA, Berg EL. J Biomol Screen. 2013 Dec;18(10):1143-55

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